/* «La scienza» — sezioni della narrativa clinica: cifre, confronto 660/405, atlante, cronologia, integrazioni, dose, voci */
.cf-sh{display:grid;grid-template-columns:5fr 7fr;gap:24px 56px;align-items:end;margin-bottom:40px}
.cf-sh h2{font-weight:400;font-size:clamp(30px,3.2vw,46px);line-height:1.08;letter-spacing:-.025em;margin:10px 0 0;max-width:17ch}
.cf-sh p{font-family:var(--serif);font-size:clamp(17px,1.3vw,19px);line-height:1.45;margin:0;max-width:52ch}
@media (max-width:900px){.cf-sh{grid-template-columns:1fr}}

/* cifre d'apertura */
.cf-kpi{display:grid;grid-template-columns:repeat(4,1fr);border-top:1px solid var(--line)}
.cf-kpi div{padding:22px 20px 0 0}
.cf-kpi b{display:block;font-weight:300;font-size:clamp(34px,3.4vw,52px);letter-spacing:-.03em;line-height:1;font-variant-numeric:tabular-nums}
.cf-kpi span{display:block;margin-top:10px;font-size:13px;line-height:1.4;max-width:26ch}
.cf-kpi small{display:block;margin-top:6px;font-size:11px;color:var(--ink-2)}
@media (max-width:900px){.cf-kpi{grid-template-columns:1fr 1fr;row-gap:24px}}

/* confronto 660/405 */
.wlc{display:grid;grid-template-columns:5fr 7fr;gap:20px}
.wlc__spec{background:#fff;border-radius:var(--r);padding:28px}
.wlc__tog{display:inline-flex;padding:3px;border-radius:6px;background:var(--panel);margin-bottom:22px}
.wlc__tog button{border:0;background:transparent;padding:8px 16px;border-radius:4px;font-size:12px;font-weight:500;letter-spacing:.9px;cursor:pointer;color:var(--ink-2)}
.wlc__tog button[aria-pressed="true"]{background:#fff;color:var(--ink);box-shadow:0 1px 2px rgba(0,0,0,.08)}
.wlc__big{font-weight:300;font-size:clamp(56px,6vw,88px);letter-spacing:-.04em;line-height:.9;color:var(--wl)}
.wlc__big small{font-size:.32em;letter-spacing:0;color:var(--ink);margin-left:6px}
.wlc__sub{font-family:var(--serif);font-size:18px;line-height:1.4;margin:14px 0 0}
.wlc dl{margin:22px 0 0;display:grid;grid-template-columns:auto 1fr}
.wlc dt,.wlc dd{padding:12px 0;border-top:1px solid var(--line);margin:0;font-size:14px;line-height:1.4}
.wlc dt{color:var(--ink-2);padding-right:18px;font-size:11px;letter-spacing:.7px;text-transform:uppercase;padding-top:14px}
.wlc__chart{background:#fff;border-radius:var(--r);padding:24px;display:flex;flex-direction:column;margin:0;min-width:0}
.wlc__chart svg{width:100%;height:auto;display:block}
.wlc__chart text{font-family:var(--sans);font-size:12px;fill:var(--ink)}
.wlc__chart .ax{stroke:var(--line);fill:none}
.wlc__chart .hb{fill:none;stroke:var(--ink);stroke-width:1.8}
.wlc__chart .mk{stroke:var(--wl);stroke-width:2}
.wlc__chart .mkd{fill:var(--wl)}
.wlc__chart .off{opacity:.25}
.wlc__chart figcaption{font-size:12px;color:var(--ink-2);margin-top:12px;line-height:1.45}
.wlc__ev{margin-top:20px;display:grid;grid-template-columns:1fr 1fr;gap:12px}
.wlc__ev div{background:var(--panel);border-radius:8px;padding:14px 16px;font-size:13px;line-height:1.4}
.wlc__ev b{display:block;font-weight:500;margin-bottom:4px}
.wlc__ev cite{display:block;font-style:normal;font-size:11px;color:var(--ink-2);margin-top:6px}
@media (max-width:980px){.wlc{grid-template-columns:1fr}.wlc__ev{grid-template-columns:1fr}}

/* atlante clinico */
.at{display:grid;grid-template-columns:270px 1fr;gap:20px;align-items:start}
.at__side{position:sticky;top:20px}
.at__tabs{display:flex;flex-direction:column;gap:2px}
.at__tab{display:flex;justify-content:space-between;align-items:center;gap:10px;text-align:left;border:0;background:transparent;padding:11px 14px;border-radius:6px;font-size:14px;cursor:pointer;color:var(--ink);position:relative}
.at__tab i{font-style:normal;font-size:11px;color:var(--ink-2);font-variant-numeric:tabular-nums}
.at__tab:hover{background:rgba(0,0,0,.035)}
.at__tab[aria-selected="true"]{background:#fff;box-shadow:0 1px 2px rgba(0,0,0,.06)}
.at__tab[aria-selected="true"]::before{content:"";position:absolute;left:0;top:10px;bottom:10px;width:2px;background:var(--wl);border-radius:2px}
.at__via{display:flex;flex-wrap:wrap;gap:6px;margin-top:20px}
.at__via button{border:1px solid var(--line);background:transparent;border-radius:999px;padding:6px 12px;font-size:12px;cursor:pointer;color:var(--ink-2)}
.at__via button[aria-pressed="true"]{border-color:var(--ink);color:var(--ink);background:#fff}
.at__count{display:block;margin-top:14px;font-size:12px;color:var(--ink-2)}
.at__main{background:#fff;border-radius:var(--r);padding:32px;min-width:0}
.at__head{display:grid;grid-template-columns:auto 1fr;gap:32px;align-items:end;padding-bottom:24px;border-bottom:1px solid var(--ink)}
.at__big b{display:block;font-weight:300;font-size:clamp(46px,5vw,72px);letter-spacing:-.04em;line-height:.95;color:var(--wl);font-variant-numeric:tabular-nums;white-space:nowrap}
.at__big span{display:block;font-size:12px;margin-top:8px;max-width:24ch;line-height:1.35}
.at__lead{font-family:var(--serif);font-size:clamp(17px,1.3vw,19px);line-height:1.45;margin:0}
.at__list{list-style:none;margin:0;padding:0}
.at__row{display:grid;grid-template-columns:1fr 210px 170px;gap:24px;padding:18px 0;border-bottom:1px solid var(--line);animation:atin .35s var(--ease) both}
@keyframes atin{from{opacity:0;transform:translateY(6px)}}
.at__t b{display:block;font-weight:500;font-size:15px;line-height:1.3;margin-bottom:5px}
.at__t span{display:block;font-size:14px;line-height:1.45;color:var(--ink-2)}
.at__dsg{display:inline-block;font-style:normal;font-size:11px;font-weight:600;letter-spacing:.7px;text-transform:uppercase;padding:4px 8px;border-radius:4px;background:var(--panel)}
.at__dsg--rct{background:var(--ink);color:#fff}
.at__dsg--rev{background:var(--wl);color:#fff}
.at__m small{display:block;margin-top:8px;font-size:12px;line-height:1.4;color:var(--ink-2)}
.at__src{font-style:normal;font-size:12px;line-height:1.4;color:var(--ink-2)}
.at__empty{padding:24px 0;color:var(--ink-2);font-size:14px}
@media (max-width:1100px){.at__row{grid-template-columns:1fr 200px}.at__src{grid-column:1/-1}}
@media (max-width:900px){.at{grid-template-columns:1fr}.at__side{position:static}.at__tabs{flex-direction:row;overflow-x:auto;gap:4px;padding-bottom:6px}.at__tab{white-space:nowrap;flex:none}.at__tab[aria-selected="true"]::before{display:none}
  .at__main{padding:20px}.at__head{grid-template-columns:1fr;gap:12px}.at__row{grid-template-columns:1fr;gap:8px}}
@media (prefers-reduced-motion:reduce){.at__row,.int__seq li{animation:none}}

/* cronologia */
.tl__sc{overflow-x:auto;scroll-snap-type:x mandatory;scrollbar-width:none}
.tl__sc::-webkit-scrollbar{display:none}
.tl__track{list-style:none;margin:0;padding:8px 0 0;display:flex}
.tl__it{flex:0 0 300px;scroll-snap-align:start;padding:0 28px 0 0;position:relative;border-top:1px solid var(--ink)}
.tl__it::before{content:"";position:absolute;top:-5px;left:0;width:9px;height:9px;border-radius:50%;background:var(--bg);border:1px solid var(--ink)}
.tl__it--key::before{background:var(--wl);border-color:var(--wl)}
.tl__y{display:block;margin:22px 0 10px;font-weight:300;font-size:40px;letter-spacing:-.03em;line-height:1;font-variant-numeric:tabular-nums}
.tl__it--key .tl__y{color:var(--wl)}
.tl__it b{display:block;font-weight:500;font-size:15px;line-height:1.3;margin-bottom:6px}
.tl__it p{font-size:14px;line-height:1.45;color:var(--ink-2);margin:0}
.tl__it cite{display:block;font-style:normal;font-size:11px;color:var(--ink-2);margin-top:10px}
.tl__nav{display:flex;align-items:center;gap:16px;margin-top:32px}
.tl__nav button{width:44px;height:44px;border-radius:50%;border:1px solid var(--ink);background:transparent;cursor:pointer;display:grid;place-items:center;color:var(--ink)}
.tl__nav button:hover{background:var(--ink);color:var(--bg)}
.tl__nav svg{width:14px;height:14px}
.tl__prog{flex:1;height:1px;background:var(--line);position:relative;overflow:hidden}
.tl__prog i{position:absolute;inset:0;background:var(--ink);transform-origin:0 0;transform:scaleX(.15)}
@media (max-width:900px){.tl__it{flex-basis:78vw}}

/* integrazioni */
.int{display:grid;grid-template-columns:320px 1fr;gap:20px;align-items:start}
.int__list{display:flex;flex-direction:column;gap:6px}
.int__btn{text-align:left;border:1px solid var(--line);background:transparent;border-radius:8px;padding:14px 16px;cursor:pointer;color:var(--ink)}
.int__btn b{display:block;font-weight:500;font-size:15px}
.int__btn small{display:block;font-size:12px;color:var(--ink-2);margin-top:3px}
.int__btn[aria-selected="true"]{background:#fff;border-color:#fff;box-shadow:0 1px 3px rgba(0,0,0,.07)}
.int__view{background:#fff;border-radius:var(--r);padding:32px;min-height:340px;min-width:0}
.int__seq{list-style:none;margin:0;padding:0;display:grid;grid-auto-flow:column;grid-auto-columns:1fr;gap:12px}
.int__seq li{position:relative;background:var(--panel);border-radius:8px;padding:18px 16px 20px;animation:atin .4s var(--ease) both}
.int__seq li:nth-child(2){animation-delay:.08s}.int__seq li:nth-child(3){animation-delay:.16s}.int__seq li:nth-child(4){animation-delay:.24s}
.int__seq li:not(:last-child)::after{content:"";position:absolute;right:-12px;top:50%;width:12px;height:1px;background:var(--ink)}
.int__seq li.is-hl{background:var(--wl);color:#fff}
.int__seq li.is-hl small{color:rgba(255,255,255,.88)}
.int__seq span{display:block;font-size:11px;font-weight:600;letter-spacing:.8px;margin-bottom:24px;opacity:.75}
.int__seq b{display:block;font-weight:500;font-size:16px;line-height:1.25}
.int__seq small{display:block;font-size:12px;line-height:1.4;color:var(--ink-2);margin-top:6px}
.int__why{font-family:var(--serif);font-size:18px;line-height:1.45;margin:28px 0 0;max-width:62ch}
.int__why b{font-family:var(--sans);font-size:11px;font-weight:600;letter-spacing:1px;text-transform:uppercase;margin-right:10px}
.int__src{display:block;font-style:normal;font-size:12px;color:var(--ink-2);margin-top:14px}
@media (max-width:980px){.int{grid-template-columns:1fr}.int__list{flex-direction:row;overflow-x:auto}.int__btn{flex:none}.int__view{padding:20px}.int__seq{grid-auto-flow:row}.int__seq li:not(:last-child)::after{display:none}}

/* dose negli studi */
.dz{background:#fff;border-radius:var(--r);padding:32px}
.dz svg{width:100%;height:auto;display:block}
.dz text{font-family:var(--sans);font-size:13px;fill:var(--ink)}
.dz .g{stroke:var(--line)}
.dz .rng{fill:var(--wl-soft)}
.dz .rngl{stroke:var(--wl);stroke-width:2}
.dz .st{fill:var(--ink)}
.dz .mut{fill:var(--ink-2)}
.dz__facts{display:grid;grid-template-columns:repeat(4,1fr);gap:20px;margin-top:28px;padding-top:24px;border-top:1px solid var(--line)}
.dz__facts b{display:block;font-weight:400;font-size:24px;letter-spacing:-.01em}
.dz__facts span{display:block;font-size:12px;color:var(--ink-2);margin-top:4px;line-height:1.4}
@media (max-width:900px){.dz{padding:16px}.dz__facts{grid-template-columns:1fr 1fr}}

/* voci dalla clinica */
.vx{display:grid;grid-template-columns:repeat(3,1fr);gap:20px}
.vx figure{margin:0;background:#fff;border-radius:var(--r);padding:28px;display:flex;flex-direction:column;justify-content:space-between;gap:24px}
.vx blockquote{margin:0;font-family:var(--serif);font-size:19px;line-height:1.4}
.vx figcaption b{display:block;font-size:14px;font-weight:500}
.vx figcaption span{display:block;font-size:12px;color:var(--ink-2);margin-top:3px;line-height:1.4}
@media (max-width:980px){.vx{grid-template-columns:1fr}}

/* sintesi */
.cf-sum__h{font-weight:400;font-size:clamp(28px,2.8vw,40px);letter-spacing:-.02em;margin:10px 0 28px}
.cf-sum{display:grid;grid-template-columns:1fr 1fr;gap:32px}
.cf-sum h3{font-size:12px;font-weight:600;letter-spacing:1.08px;text-transform:uppercase;margin:0 0 6px;padding-bottom:10px;border-bottom:1px solid var(--ink)}
.cf-sum ul{list-style:none;margin:0;padding:0}
.cf-sum li{padding:14px 0;border-bottom:1px solid var(--line);font-size:15px;line-height:1.45}
.cf-sum li span{display:block;margin-top:4px;font-size:12px;color:var(--ink-2)}
@media (max-width:760px){.cf-sum{grid-template-columns:1fr}}
.cf-hero__txt .cf-kpi{grid-column:1/-1;margin-top:8px}
.cf-note{margin-top:24px;font-size:13px;color:var(--ink-2)}
.at>*,.int>*,.wlc>*{min-width:0}
.vx figure{background:var(--panel)}
.at__main{box-shadow:0 0 0 1px var(--line)}
.wlc__chart .mut{fill:var(--ink-2)}
@media (max-width:900px){.dz__sc{overflow-x:auto;margin:0 -16px;padding:0 16px}.dz__sc svg{min-width:860px}.wlc__chart{padding:14px}.wlc__chart text{font-size:16px}}
@media (max-width:600px){.wlc dl{grid-template-columns:1fr}.wlc dt{padding-bottom:0}.wlc dd{border-top:0;padding-top:4px}.wlc__chart text{font-size:22px}.wlc__spec{padding:20px}}